Article
The region responsible for stroke on chromosome 4 in the stroke-prone spontaneously hypertensive rat.
Biochemical and biophysical research communications - 13 Dec 1996
Ikeda K, Nara Y, Matumoto C, Mashimo T, Tamada T, Sawamura M, Nabika T, Yamori Y
Abstract excerpt
To detect genetic loci responsible for stroke susceptibility, we produced 107 male F2 progenies crossed between stroke-prone spontaneously hypertensive rats (SHRSP/Izm) and normotensive Wistar Kyoto rats (WKY/Izm) and followed them up until they developed cerebral stroke. One hundred and twenty-five simple sequence repeat (SSR) markers were analyzed in these F2 rats. Nine of 107 F2 rats suffered from...
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