HTLV-1 21 bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity.

Abstract excerpt

The human T-cell leukemia virus type I (HTLV-I) transactivator protein Tax is critical for the activation of viral gene expression and the transformation of T-lymphocytes. Tax activation of HTLV-I gene expression is mediated by three highly homologous regulatory elements known as 21 bp repeats which bind the transcription factor CREB. Questions remain about the mechanism by which Tax can stimulate CREB binding,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Sequence
• Share to Binding Sites
• Share to Cell Line