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Article

Activation of CREB/ATF sites by polyomavirus large T antigen.

Journal of virology - 1 Apr 2005

Love Tara M, de Jesus Rowena, Kean Jennifer A, Sheng Qing, Leger Andrew, Schaffhausen Brian

Abstract excerpt

Polyomavirus large T antigen (LT) has a direct role in viral replication and a profound effect on cell phenotype. It promotes cell cycle progression, immortalizes primary cells, blocks differentiation, and causes apoptosis. While much of large T function is related to its effects on tumor suppressors of the retinoblastoma susceptibility (Rb) gene family, we have previously shown that activation of the cyclin A...

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Identifiers

PMID: 15767419
DOI: 10.1128/JVI.79.7.4180-4190.2005
PMCID: PMC1061560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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