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Article

Heat shock of human synovial and dermal fibroblasts induces delayed up-regulation of collagenase-gene expression.

The Biochemical journal - 15 Jun 1995

Hitraya E G, Varga J, Jimenez S A

Abstract excerpt

We investigated the effect of heat shock on the expression of the collagenase gene in normal human synovial and dermal fibroblasts. Heat shock (42-44 degrees C for 1 h) caused a marked increase in heat-shock protein 70 (HSP-70) mRNA levels, followed by a delayed increase in collagenase mRNA levels, in both cell types. Pretreatment with cycloheximide had no effect on the heat-shock-induced increase in HSP-70 mRNA...

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PMID: 8948427
DOI: 10.1042/bj3080743
PMCID: PMC1136787

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CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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