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Article

Enhancement of glucocorticoid receptor-mediated gene expression by constitutively active heat shock factor 1.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004

Jones Thomas J, Li Dapei, Wolf Irene M, Wadekar Subhagya A, Periyasamy Sumudra, Sánchez Edwin R

Abstract excerpt

To further define the role of heat shock factor 1 (HSF1) in the stress potentiation of glucocorticoid receptor (GR) activity, we placed a constitutively active mutant of human HSF1 (hHSF1-E189) under the control of a doxycycline (DOX)-inducible vector. In mouse L929 cells, DOX-induced expression of hHSF1-E189 correlated with in vivo occupancy of the human heat shock protein 70 (hHsp70) promoter...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Glucocorticoid

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Source

Identifiers

PMID: 14673135
DOI: 10.1210/me.2003-0366

Genes

HSF1
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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