Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disposition of debrisoquine and nortriptyline in Korean subjects in relation to CYP2D6 genotypes, and comparison with Caucasians.

British journal of clinical pharmacology - 1 Jun 2003

Dalén P, Dahl M-L, Roh H-K, Tybring G, Eichelbaum M, Wilkinson G R, Bertilsson L

Abstract excerpt

AIMS: To study the influence of the CYP2D6*10 allele on the disposition of debrisoquine and nortriptyline. METHODS: The pharmacokinetics of debrisoquine and nortriptyline and their main metabolites were determined in ten Koreans with the CYP2D6*1/*1 (n = 5) and CYP2D6*1/*10 (n = 5) genotypes afte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents, Tricyclic
Share to Asian People
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Debrisoquin

Share to Genotype

Share to Homozygote

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 12814461
DOI: 10.1046/j.1365-2125.2003.01804.x
PMCID: PMC1884261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12814461-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disposition of debrisoquine and nortriptyline in Korean subjects in relation to CYP2D6 genotypes, and comparison with Caucasians.PMID 12814461Read ↗

Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes.Semantic proximity Read ↗

Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population.Semantic proximity Read ↗

Genetic analysis of the CYP2D6 locus in a Hong Kong Chinese population.Semantic proximity Read ↗

Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes.Semantic proximity Read ↗

CYP2D6 allele frequencies in Korean population, comparison with East Asian, Caucasian and African populations, and the comparison of metabolic activity of CYP2D6 genotypes.Semantic proximity Read ↗

CYP2D6 phenotypes among Malays in Malaysia.Semantic proximity Read ↗

Lack of association in Japanese patients between neuroleptic malignant syndrome and a debrisoquine 4-hydroxylase genotype with low enzyme activity.Semantic proximity Read ↗

Sequence-based CYP2D6 genotyping in the Korean population.Semantic proximity Read ↗

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19.Semantic proximity Read ↗

Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects.Semantic proximity Read ↗

Substrate specificity of CYP2D6 genetic variants.Semantic proximity Read ↗

New allelic arrangement CYP2D6*36 x 2 found in a Japanese poor metabolizer of debrisoquine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.