Article
Allelic imbalance in mammary carcinomas induced by either 7,12-dimethylbenz[a]anthracene or ionizing radiation in rats carrying genes conferring differential susceptibilities to mammary carcinogenesis.
Molecular carcinogenesis - 1 Nov 1996
Haag J D, Hsu L C, Newton M A, Gould M N
Abstract excerpt
To identify and compare the genetic lesions associated with tumorigenesis in rats carrying the mammary carcinoma suppressor (MCS) 1 gene, we induced mammary carcinomas in (Wistar Furth (WF) x Copenhagen (Cop))F1 rats by using either 7,12-dimethylbenz[a]anthracene (DMBA) or radiation. The tumors w...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Alleles
- Animals
- Carcinogens
- Chromosomes
- DNA, Neoplasm
- Disease Susceptibility
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Genes, ras
- Genome
- Heterozygote
- Mammary Neoplasms, Experimental
- Mutation
- Neoplasms, Radiation-Induced
- Phenotype
- Rats