Article
Carboxy-terminal region of the yeast heat shock factor contains two domains that make transcription independent of the TFIIH protein kinase.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2003
Sakurai Hiroshi, Hashikawa Naoya, Imazu Hiromi, Fukasawa Toshio
Abstract excerpt
BACKGROUND: Phosphorylation of the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II is implicated in transition from initiation to elongation in the transcription cycle. In yeast cells, Kin28, a subunit of the general transcription factor TFIIH, is responsible for the CTD phosphorylation. Although Kin28 is indispensable for transcription of many genes, its requirement is bypassed in...
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