Article
Role of the terminal repeat GAGC trimer, the major Rep78 binding site, in adeno-associated virus DNA replication.
FEBS letters - 11 Nov 1996
Bishop B M, Santin A D, Quirk J G, Hermonat P L
Abstract excerpt
The adeno-associated virus (AAV) terminal repeats (TR) are cis required, and the AAV encoded Rep78 protein is trans required, for AAV DNA replication. The Rep78 protein recognizes and interacts with at least three regions within the TR DNA. The major binding site, with the highest affinity for Re...
Topics
- Base Sequence
- Binding Sites
- DNA Replication
- DNA, Single-Stranded
- DNA, Viral
- DNA-Binding Proteins
- Dependovirus
- Genome, Viral
- Molecular Sequence Data
- Mutation
- Repetitive Sequences, Nucleic Acid
- Transfection