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Article

Impact of capsid conformation and Rep-capsid interactions on adeno-associated virus type 2 genome packaging.

Journal of virology - 1 Jan 2006

Bleker Svenja, Pawlita Michael, Kleinschmidt Jürgen A

Abstract excerpt

Single-stranded genomes of adeno-associated virus (AAV) are packaged into preformed capsids. It has been proposed that packaging is initiated by interaction of genome-bound Rep proteins to the capsid, thereby targeting the genome to the portal of encapsidation. Here we describe a panel of mutants with amino acid exchanges in the pores at the fivefold axes of symmetry on AAV2 capsids with reduced packaging and...

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Identifiers

PMID: 16378983
DOI: 10.1128/JVI.80.2.810-820.2006
PMCID: PMC1346863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impact of capsid conformation and Rep-capsid interactions on adeno-associated virus type 2 genome packaging.PMID 16378983Read ↗

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