Adeno-associated virus type 2 DNA replication in vivo: mutation analyses of the D sequence in viral inverted terminal repeats.

doi:10.1128/JVI.71.4.3077-3082.1997

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Article

Adeno-associated virus type 2 DNA replication in vivo: mutation analyses of the D sequence in viral inverted terminal repeats.

Journal of virology - 1 Apr 1997

Wang X S, Qing K, Ponnazhagan S, Srivastava A

Abstract excerpt

The adeno-associated virus type 2 (AAV) genome contains inverted terminal repeats (ITRs) of 145 nucleotides. The terminal 125 nucleotides of each ITR form palindromic hairpin (HP) structures that serve as primers for AAV DNA replication. These HP structures also play an important role in integrat...

Topics

DNA Replication
DNA, Viral
DNA-Binding Proteins
Dependovirus
Humans
Mutation
Repetitive Sequences, Nucleic Acid
Tumor Cells, Cultured
Virus Assembly

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