Article
The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Structure (London, England : 1993) - 15 Oct 1996
Groves M R, Taylor M A, Scott M, Cummings N J, Pickersgill R W, Jenkins J A
Abstract excerpt
BACKGROUND: Cysteine proteases are involved in a variety of cellular processes including cartilage degradation in arthritis, the progression of Alzheimer's disease and cancer invasion: these enzymes are therefore of immense biological importance. Caricain is the most basic of the cysteine proteases found in the latex of Carica papaya. It is a member of the papain superfamily and is homologous to other plant and...
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