Article
The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Structure (London, England : 1993) - 15 Oct 1996
Groves M R, Taylor M A, Scott M, Cummings N J, Pickersgill R W, Jenkins J A
Abstract excerpt
BACKGROUND: Cysteine proteases are involved in a variety of cellular processes including cartilage degradation in arthritis, the progression of Alzheimer's disease and cancer invasion: these enzymes are therefore of immense biological importance. Caricain is the most basic of the cysteine proteas...
Topics
- Amino Acid Chloromethyl Ketones
- Amino Acid Sequence
- Cathepsin B
- Computer Simulation
- Crystallography, X-Ray
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- Enzyme Activation
- Enzyme Precursors
- Fruit
- Hydrogen Bonding
- Leucine
- Leupeptins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Papain