The globular head domain of titin extends into the center of the sarcomeric m band: cdna cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins

Abstract excerpt

Immunoelectron microscopical results have shown that the Z and M bands of the sarcomere are interconnected by the long titin molecules. Here we have characterized by monoclonal antibodies, cDNA cloning and immunoelectron microscopy the two titin-associated proteins (190 and 165 kDa proteins), which seem responsible for the formation of a head structure on one end of the 0.9 micron long titin string. The human 165...

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