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Article

Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

13 Oct 1995

Abstract excerpt

In addition to thick and thin filaments, vertebrate striated muscle contains a third filament system formed by the giant protein titin. Single titin molecules extend from Z discs to M lines and are longer than 1 micrometer. The titin filament contributes to muscle assembly and resting tension, but more details are not known because of the large size of the protein. The complete complementary DNA sequence of human...

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PMID: 7569978
DOI: 10.1126/science.270.5234.293

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