Article
HLA allele selection for designing peptide vaccines.
Genetic analysis : biomolecular engineering - 1 Sept 1996
Gulukota K, DeLisi C
Abstract excerpt
A central problem in developing vaccines against rapidly evolving viruses such as HIV and Influenza is the mutability of their antigens. In principle, the problem can be mitigated by using peptides from conserved portions of viral proteins. However, because cytotoxic T lymphocytes (CTLs), which such vaccines would stimulate, recognize pathogenic peptides only in association with class I products of the Major...
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