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Article

Predicting population coverage of T-cell epitope-based diagnostics and vaccines.

BMC bioinformatics - 17 Mar 2006

Bui Huynh-Hoa, Sidney John, Dinh Kenny, Southwood Scott, Newman Mark J, Sette Alessandro

Abstract excerpt

BACKGROUND: T cells recognize a complex between a specific major histocompatibility complex (MHC) molecule and a particular pathogen-derived epitope. A given epitope will elicit a response only in individuals that express an MHC molecule capable of binding that particular epitope. MHC molecules are extremely polymorphic and over a thousand different human MHC (HLA) alleles are known. A disproportionate amount of...

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Identifiers

PMID: 16545123
DOI: 10.1186/1471-2105-7-153
PMCID: PMC1513259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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