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Article

Ramifications of HLA class I polymorphism and population genetics for vaccine development.

Genetic epidemiology - 1 Jan 2001

Dawson D V, Ozgur M, Sari K, Ghanayem M, Kostyu D D

Abstract excerpt

HLA polymorphism can complicate the design and development of vaccines, especially those that contain a selected number of epitopes and are directed at pathogens prevalent worldwide. Because of HLA class I restricted antigen recognition and ethnic variation in HLA distribution, such vaccines may not be uniformly effective across populations. We, therefore, considered whether it is possible to assemble a panel of...

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Identifiers

PMID: 11119299
DOI: 10.1002/1098-2272(200101)20:1<87::AID-GEPI8>3.0.CO;2-R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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