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Article

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 1996

Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe A H, Speck N A

Abstract excerpt

The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding factor. The CBFA2 gene is disrupted by the (8;21), (3;21), and (12;21) chromosomal translocations associated with leukemias and myelodysplasias in humans. Mice lacking a CBF alpha 2 protein capable of binding DN...

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Identifiers

PMID: 8622955
DOI: 10.1073/pnas.93.8.3444
PMCID: PMC39628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8622955-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.PMID 8622955Read ↗

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.Semantic proximity Read ↗

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factorSemantic proximity Read ↗

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11.Semantic proximity Read ↗

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.Semantic proximity Read ↗

Failure of Embryonic Hematopoiesis andLethal Hemorrhages in Mouse Embryos Heterozygousfor a Knocked-In Leukemia Gene CBFB–MYH11Semantic proximity Read ↗

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.Semantic proximity Read ↗

The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation.Semantic proximity Read ↗

CBFA2, frequently rearranged in leukemia, is not responsible for a familial leukemia syndrome.Semantic proximity Read ↗

Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia.Semantic proximity Read ↗

Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesisSemantic proximity Read ↗

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.Semantic proximity Read ↗

Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum.Semantic proximity Read ↗

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