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Article

Calmodulin-Cork Model of Gap Junction Channel Gating-One Molecule, Two Mechanisms.

International journal of molecular sciences - 13 Jul 2020

Peracchia Camillo

Abstract excerpt

The Calmodulin-Cork gating model is based on evidence for the direct role of calmodulin (CaM) in channel gating. Indeed, chemical gating of cell-to-cell channels is sensitive to nanomolar cytosolic calcium concentrations [Ca2+]i. Calmodulin inhibitors and inhibition of CaM expression prevent chemical gating. CaMCC, a CaM mutant with higher Ca2+-sensitivity greatly increases chemical gating sensitivity (in CaMCC...

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Identifiers

PMID: 32668628
DOI: 10.3390/ijms21144938
PMCID: PMC7404200

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