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Article

Calmodulin Binding to Connexin 35: Specializations to Function as an Electrical Synapse.

International journal of molecular sciences - 1 Sept 2020

Aseervatham Jaya, Li Xiaofan, Mitchell Cheryl K, Lin Ya-Ping, Heidelberger Ruth, O'Brien John

Abstract excerpt

Calmodulin binding is a nearly universal property of gap junction proteins, imparting a calcium-dependent uncoupling behavior that can serve in an emergency to decouple a stressed cell from its neighbors. However, gap junctions that function as electrical synapses within networks of neurons routinely encounter large fluctuations in local cytoplasmic calcium concentration; frequent uncoupling would be impractical...

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Identifiers

PMID: 32882943
DOI: 10.3390/ijms21176346
PMCID: PMC7504508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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