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Article

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas.

Nature - 14 Oct 1993

Parma J, Duprez L, Van Sande J, Cochaux P, Gervy C, Mockel J, Dumont J, Vassart G

Abstract excerpt

The pituitary hormone thyrotropin stimulates the function, expression of differentiation and growth of thyrocytes by cyclic AMP-dependent mechanisms. Tissue hyperplasia and hyperthyroidism are therefore expected to result when activation of the adenylyl cyclase-cAMP cascade is unregulated. This is observed in several situations, including when somatic mutations impair the GTPase activity of the G protein Gsa (ref...

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Identifiers

PMID: 8413627
DOI: 10.1038/365649a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas.PMID 8413627Read ↗

Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid.Semantic proximity Read ↗

Thyrotropin receptor mutations in hyperfunctioning thyroid adenomas from Brazil.Semantic proximity Read ↗

Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signalling in thyroid hyperfunctioning adenomas.Semantic proximity Read ↗

Mutations of thyrotropin receptor gene.Semantic proximity Read ↗

Gs alpha mutations in hyperfunctioning thyroid adenomas.Semantic proximity Read ↗

Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas.Semantic proximity Read ↗

Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy.Semantic proximity Read ↗

Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.Semantic proximity Read ↗

Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.Semantic proximity Read ↗

Thyrotropin receptor mutations in hyperfunctioning thyroid adenomas: new mutants, new second messenger and new frequency.Semantic proximity Read ↗

Constitutive activities in the thyrotropin receptor: regulation and significance.Semantic proximity Read ↗

Functional significance of the thyrotropin receptor germline polymorphism D727E.Semantic proximity Read ↗

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