Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas.

doi:10.1038/365649a0

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Article

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas.

Nature - 14 Oct 1993

Parma J, Duprez L, Van Sande J, Cochaux P, Gervy C, Mockel J, Dumont J, Vassart G

Abstract excerpt

The pituitary hormone thyrotropin stimulates the function, expression of differentiation and growth of thyrocytes by cyclic AMP-dependent mechanisms. Tissue hyperplasia and hyperthyroidism are therefore expected to result when activation of the adenylyl cyclase-cAMP cascade is unregulated. This i...

Topics

Adenoma
Adenylyl Cyclases
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Colforsin
Cyclic AMP
DNA Mutational Analysis
DNA Primers
DNA, Neoplasm
Enzyme Activation
GTP-Binding Proteins
Humans
Hyperthyroidism
Inositol Phosphates
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 8413627
DOI: 10.1038/365649a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8413627-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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