Article
Effect of overexpression of E. coli 3-methyladenine-DNA glycosylase I (Tag) on survival and mutation induction in Salmonella typhimurium.
Mutation research - 28 Oct 1996
Tomicic M, Franekic J
Abstract excerpt
Salmonella typhimurium, compared to Escherichia coli, is deficient in an inducible glycosylase activity harbouring only constitutive glycosylase functions. 3-Methyladenine-DNA glycosylase I encoded by the E. coli tag gene is a constitutively expressed repair enzyme that primarily removes N3-methyladenine but also N3-methylguanine from DNA by glycosylic cleavage in the first step of the base excision repair. In...
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