Article
The effect of methylation on some biological parameters in Salmonella enterica serovar Typhimurium.
Pathologie-biologie - 1 Aug 2011
Aloui A, Tagourti J, El May A, Joseleau Petit D, Landoulsi A
Abstract excerpt
Cell growth is tightly coupled to DNA replication and its methylation [Proc Natl Acad Sci U S A 93 (1996) 12206-12211]. In a culture medium, growing of Salmonella Typhimurium (S. Typhimurium) mutant cells (dam⁻) decreased (2.5 fold) relative to the wild type strain (dam⁺). In this study, we show that the reason for this growth deficiency is due to the DNA methylation. The absence of a Dam methyltransferase...
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