Article
Mutation induction by N-propyl-N-nitrosourea in eight MutaMouse organs.
Mutation research - 18 Aug 1999
Hara T, Hirano K, Hirano N, Tamura H, Sui H, Shibuya T, Hyogo A, Hirashio T, Tokai H, Yamashita Y, Kura K
Abstract excerpt
As a part of the 2nd Collaborative Study for the Transgenic Mouse Mutation Assay, we studied the organ specificity and the temporal changes in mutant frequency (MF) of the lacZ gene following intraperitoneal injection of 250 mg/kg N-propyl-N-nitrosourea into male MutaMouse. We used a positive selection system and examined eight organs, i.e., bone marrow, liver, kidney, lung, spleen, brain, heart, and testis. The...
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