[Review of the molecular genetics of the Lynch syndrome].

Article

[Review of the molecular genetics of the Lynch syndrome].

Ceskoslovenska fysiologie - 1 Mar 1998

Dolezal T, Panczak A, Krepelová A

Abstract excerpt

The molecular genetics of the hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is reviewed. Recently, four genes (hMSH2, hMLH1, hPMS1, hPMS2) whose mutations are related to HNPCC were discovered. The products of these genes are homologues of the bacterial mismatch repair (MMR) sy...

Topics

Colorectal Neoplasms, Hereditary Nonpolyposis
DNA, Neoplasm
Humans
Microsatellite Repeats
Mutation
Repetitive Sequences, Nucleic Acid

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