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Article

[Review of the molecular genetics of the Lynch syndrome].

Ceskoslovenska fysiologie - 1 Mar 1998

Dolezal T, Panczak A, Krepelová A

Abstract excerpt

The molecular genetics of the hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is reviewed. Recently, four genes (hMSH2, hMLH1, hPMS1, hPMS2) whose mutations are related to HNPCC were discovered. The products of these genes are homologues of the bacterial mismatch repair (MMR) system proteins MutS and MutL. Dysfunction of MMR system both in bacterial and human cells leads to the microsatellite...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Share to Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 9650415

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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[Review of the molecular genetics of the Lynch syndrome].PMID 9650415Read ↗

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[The Lynch syndrome].Semantic proximity Read ↗

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[Disruption of mismatch repair system in human cancers].Semantic proximity Read ↗

Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives.Semantic proximity Read ↗

Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review).Semantic proximity Read ↗

[Lynch syndrome and microsatellite instability: a review].Semantic proximity Read ↗

Genes involved in hereditary nonpolyposis colorectal carcinoma.Semantic proximity Read ↗

[Founder mutation in Lynch syndrome].Semantic proximity Read ↗

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