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TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2019

Kovalčíkova Jana, Vrbacký Marek, Pecina Petr, Tauchmannová Kateřina, Nůsková Hana, Kaplanová Vilma, Brázdová Andrea, Alán Lukáš, Eliáš Jan, Čunátová Kristýna, Kořínek Vladimír, Sedlacek Radislav, Mráček Tomáš, Houštěk Josef

Abstract excerpt

Biogenesis of F1Fo ATP synthase, the key enzyme of mitochondrial energy provision, depends on transmembrane protein 70 (TMEM70), localized in the inner mitochondrial membrane of higher eukaryotes. TMEM70 absence causes severe ATP-synthase deficiency and leads to a neonatal mitochondrial encephalocardiomyopathy in humans. However, the exact biochemical function of TMEM70 remains unknown. Using TMEM70 conditional...

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PMID: 31652072
DOI: 10.1096/fj.201900685RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme.PMID 31652072Read ↗

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