Article
ATP-induced protein-Hsp70 complex dissociation requires K+ but not ATP hydrolysis.
Nature - 14 Oct 1993
Palleros D R, Reid K L, Shi L, Welch W J, Fink A L
Abstract excerpt
The molecular chaperone proteins, particularly Hsp60 and Hsp70, have been implicated in essential cell functions under both normal and stress conditions (reviewed in refs 1-5). Members of the family of heat-shock proteins of M(r) 70K, Hsp70, bind to unfolded proteins and short peptides. Addition of Mg-ATP results in the dissociation of the substrate polypeptides from the chaperone, but as ATP-gamma S (an ATP...
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