Enhancement of tumor cell susceptibility to lymphokine-activated killer cells by treatment with the streptococcal preparation OK432.

doi:10.1007/BF02194788

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Article

Enhancement of tumor cell susceptibility to lymphokine-activated killer cells by treatment with the streptococcal preparation OK432.

Biotherapy (Dordrecht, Netherlands) - 1 Jan 1992

Yamaue H, Tanimura H, Tsunoda T, Iwahashi M, Tani M, Tamai M, Noguchi K, Hotta T, Arii K

Abstract excerpt

We investigated whether tumor cell lysis by LAK cells was augmented by treatment with OK432 in vitro. NK and LAK activity against K562 cells was not enhanced by their treatment with OK432. In contrast, the susceptibility of OK432-treated Daudi and KATO-III cells to lysis by LAK cells was enhanced. Succinate dehydrogenase activity and RNA synthesis were impaired in Daudi and KATO-III cells by treatment with OK432,...

Topics

Antigens, Neoplasm
Antigens, Surface
Burkitt Lymphoma
DNA, Neoplasm
Humans
Immunotherapy, Adoptive
Killer Cells, Lymphokine-Activated
Leukemia, Myeloid, Acute
Neoplasms, Experimental
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Picibanil

RNA, Neoplasm

Sensitivity and Specificity

Stomach Neoplasms

Succinate Dehydrogenase

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1389905
DOI: 10.1007/BF02194788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1389905-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Enhancement of tumor cell susceptibility to lymphokine-activated killer cells by treatment with the streptococcal preparation OK432.PMID 1389905Read ↗

Effects of OK-432 on the proliferation and cytotoxicity of lymphokine-activated killer (LAK) cells.Semantic proximity Read ↗

Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.Semantic proximity Read ↗

Interference of the induction of suppressor cells by a streptococcal preparation, OK-432 through the blocking of suppressor inducer T-cells.Semantic proximity Read ↗

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