Article
Transcription factor AP-2beta genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Apr 2004
Damberg M, Berggård C, Farde L, Sedvall G C, Jönsson E G
Abstract excerpt
Transcription factor AP-2beta has been suggested to influence brain monoaminergic systems by regulating target genes. In order to explore a possible functional role, AP-2beta genotype was analysed in relation to striatal dopamine D2 receptor density determined in vivo by positron emission tomography in human subjects (n = 52). The AP-2beta genotype was also analysed in relation to cerebrospinal fluid (CSF)...
Topics
- Adult
- Analysis of Variance
- Autoradiography
- Biogenic Amines
- Corpus Striatum
- DNA-Binding Proteins
- Female
- Genotype
- Humans
- Hydroxyindoleacetic Acid
- Male
- Methoxyhydroxyphenylglycol
- Raclopride
- Receptors, Dopamine D2
