Article
Effects of 2',3'-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis.
Antimicrobial agents and chemotherapy - 1 May 1994
Faraj A, Fowler D A, Bridges E G, Sommadossi J P
Abstract excerpt
2',3'-Dideoxynucleosides (ddNs) including 3'-azido-3'-deoxythymidine (AZT), 3'-fluoro-3'-deoxythymidine (FLT), 3'-amino-3'-deoxythymidine (AMT), 2',3'-dideoxycytidine (ddC), and 2',3'-didehydro-3'-deoxythymidine (D4T) were tested for their effects on proliferation and differentiation of pluripotent progenitor cells (CD34+) purified from human bone marrow cells grown in liquid cultures. These highly purified...
Topics
- Antibody Specificity
- Antigens, CD
- Antigens, CD34
- Bone Marrow
- Bone Marrow Cells
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Colony-Forming Units Assay
- DNA
- Dideoxynucleosides