Article
Metabolic pathways for the activation of the antiviral agent 2',3'-dideoxyguanosine in human lymphoid cells.
Molecular pharmacology - 1 Sept 1992
Bondoc L L, Ahluwalia G, Cooney D A, Hartman N R, Johns D G, Fridland A
Abstract excerpt
2',3'-Dideoxyguanosine (ddGuo) is a selective inhibitor of the replication of human immunodeficiency virus in vitro and the most active antihepadnavirus nucleoside analog known in vitro and in vivo, in a Peking duck model. However, the exact route by which this and related guanosine analogs are a...
Topics
- Adenosine Kinase
- Antiviral Agents
- Biotransformation
- Cell Division
- Cell Extracts
- Deoxycytidine Kinase
- Dideoxynucleosides
- Humans
- Lymphocytes
- Mutation
- Nucleosides
- Nucleotides
- Phosphorylation
- Phosphotransferases
- Tritium