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Article

Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.

Antimicrobial agents and chemotherapy - 1 Jul 2002

Balzarini J, Pannecouque C, De Clercq E, Aquaro S, Perno C-F, Egberink H, Holý A

Abstract excerpt

A novel class of acyclic nucleoside phosphonates has been discovered in which the base consists of a pyrimidine preferably containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy (PMEO) or a 2-(phosphonomethoxy)propoxy (PMPO) group at C-6. The 6-PMEO 2,4-diaminopyrimidine (compound 1) and 6-PMPO 2,4-diaminopyrimidine (compound 11) derivatives showed potent activity against human immunodeficiency...

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Identifiers

PMID: 12069973
DOI: 10.1128/AAC.46.7.2185-2193.2002
PMCID: PMC127315

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Source receipt: pubmed, retrieved 7 Sept 2026.

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