Article

Dynamical rearrangement of human epidermal growth factor receptor 2 upon antibody binding: effects on the dimerization

2019-08-30

Abstract excerpt

Human epidermal growth factor 2 (HER2) is a ligand-free tyrosine kinase receptor of the HER family that is overexpressed in some of the most aggressive tumours. Treatment of HER2+ breast cancers with the humanized monoclonal anti-HER2 antibody (Trastuzumab) revealed highly effective, encouraging the development of various HER2-specific antibodies, kinase inhibitors and dimerization inhibitors for cancer therapy. A...

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Literature Corpus work: a25287ec-1fd2-571f-80ba-29eacaec11ed
DOI: 10.1101/752980

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