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Article

Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2008

Lázár-Molnár Eszter, Yan Qingrong, Cao Erhu, Ramagopal Udupi, Nathenson Stanley G, Almo Steven C

Abstract excerpt

Programmed death-1 (PD-1) is a member of the CD28/B7 superfamily that delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. The high-resolution crystal structure of the complex formed by the complete ectodomains of murine PD-1 and PD-L2 revealed a 1:1 receptor:ligand stoichiometry and displayed a binding interface and overall molecular organization distinct from that observed in the...

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Share to Antigens, Surface
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18641123
DOI: 10.1073/pnas.0804453105
PMCID: PMC2492495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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