Article
HLA-DRB1 genes and disease severity in rheumatoid arthritis. The MIRA Trial Group. Minocycline in Rheumatoid Arthritis.
Arthritis and rheumatism - 1 Nov 1996
Reveille J D, Alarcón G S, Fowler S E, Pillemer S R, Neuner R, Clegg D O, Mikhail I S, Trentham D E, Leisen J C, Bluhm G, Cooper S M, Duncan H, Tuttleman M, Heyse S P, Sharp J T, Tilley B
Abstract excerpt
OBJECTIVE: To examine the effect of alleles encoding the "shared"/"rheumatoid" epitope on rheumatoid arthritis (RA) disease severity in patients who participated in the minocycline in RA (MIRA) trial. METHODS: Of 205 patients with a week-48 visit, blood was available for typing of HLA-DRB1 and HLA-DQB1 in 174 (85%) and successfully completed in 169 (82%). Baseline erosions were used to assess disease severity and...
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