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Article

Effect of the CYP2C19 oxidation polymorphism on fluoxetine metabolism in Chinese healthy subjects.

British journal of clinical pharmacology - 1 Jul 2001

Liu Z Q, Cheng Z N, Huang S L, Chen X P, Ou-Yang D S, Jiang C H, Zhou H H

Abstract excerpt

AIMS: The study was designed to investigate whether genetically determined CYP2C19 activity affects the metabolism of fluoxetine in healthy subjects. METHODS: A single oral dose of fluoxetine (40 mg) was administrated successively to 14 healthy young men with high (extensive metabolizers, n=8) and low (poor metabolizers, n = 6) CYP2C19 activity. Blood samples were collected for 5-7 half-lives and fluoxetine, and...

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Identifiers

PMID: 11453896
DOI: 10.1046/j.0306-5251.2001.01402.x
PMCID: PMC2014504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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