Article
No effect of Trp64Arg beta3-adrenoceptor polymorphism on the plasma leptin concentration in Pima Indians.
Metabolism: clinical and experimental - 1 Dec 1998
Snitker S, Nicolson M, Shuldiner A R, Silver K, Ravussin E
Abstract excerpt
In rodents, administration of leptin promotes beta3-adrenergic stimulation of thermogenesis in brown adipose tissue. Conversely, administration of a beta3-adrenoceptor (beta3-AR) agonist decreases leptin mRNA expression and secretion, suggesting that leptin and sympathetic nervous system activity...
Topics
- Adult
- Alleles
- Body Composition
- Body Mass Index
- Body Weight
- Female
- Genotype
- Humans
- Indians, North American
- Insulin
- Male
- Obesity
- Polymorphism, Genetic
- Receptors, Adrenergic, beta
- Receptors, Adrenergic, beta-3
- Receptors, Leptin
- Regression Analysis