Article
The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample.
Diabetologia - 1 Feb 1999
Ghosh S, Langefeld C D, Ally D, Watanabe R M, Hauser E R, Magnuson V L, Nylund S J, Valle T, Eriksson J, Bergman R N, Tuomilehto J, Collins F S, Boehnke M
Abstract excerpt
Recent studies have suggested an association between Type II (non-insulin-dependent) diabetes mellitus-related phenotypes and a cytosine-to-thymidine substitution that results in the replacement of tryptophan by arginine at codon 64 (Trp64Arg or W64R) of the beta3-adrenergic receptor gene. Here, we present the results of possibly the largest association study to date on the variant in a sample of 526 families...
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