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Article

Fetal origins of hematopoietic failure in a murine model of Fanconi anemia

12 Jan 2013

Abstract excerpt

Hematopoietic failure is the predominant clinical manifestation of Fanconi anemia (FA), a rare, recessively inherited disorder. Mutations in 1 of 15 genes that coordinately function in a complex pathway to maintain DNA integrity also predispose patients to constitutional defects in growth and development. The hematologic manifestations have been considered to reflect the progressive loss of stem cells from the...

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PMID: 23315168
DOI: 10.1182/blood-2012-06-439679

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