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Article

The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides.

Molecular microbiology - 1 May 2005

Crouch Marie-Laure, Becker Lynne A, Bang Iel-Soo, Tanabe Hiroki, Ouellette Andre J, Fang Ferric C

Abstract excerpt

The enteric pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) encounters a variety of anti-microbial peptides during the course of infection. We report here that the extracytoplasmic sigma factor sigma(E) (RpoE) is required for Salmonella resistance to killing by the bactericidal/permeability-increasing protein (BPI)-derived peptide P2 and the murine alpha-defensin cryptdin-4 (Crp4). Moreover,...

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PMID: 15819632
DOI: 10.1111/j.1365-2958.2005.04578.x

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BPI

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