Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a.

doi:10.1111/j.1365-2958.1996.tb02656.x

Back to search

Article

Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a.

Molecular microbiology - 1 Oct 1996

Sandlin R C, Goldberg M B, Maurelli A T

Abstract excerpt

IcsA of Shigella flexneri is required for intercellular spread and is located in the outer membrane at one pole of the bacterium, where it catalyses the polymerization of host-cell actin. The formation of the a tin tail provides the force to move the bacterium in a unidirectional manner through t...

Topics

Actins
Animals
Bacterial Proteins
Carbohydrate Sequence
DNA-Binding Proteins
Escherichia coli Proteins
HeLa Cells
Hexosyltransferases
Humans
L Cells
Ligases
Membrane Proteins
Mice
Molecular Sequence Data
Mutagenesis, Insertional
Mutation
O Antigens
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.