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Article

Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a.

Molecular microbiology - 1 Oct 1996

Sandlin R C, Goldberg M B, Maurelli A T

Abstract excerpt

IcsA of Shigella flexneri is required for intercellular spread and is located in the outer membrane at one pole of the bacterium, where it catalyses the polymerization of host-cell actin. The formation of the a tin tail provides the force to move the bacterium in a unidirectional manner through the host-cell cytoplasm. We have previously demonstrated that rough lipopolysaccharide (LPS) mutants of S. flexneri 2a...

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Identifiers

PMID: 8899709
DOI: 10.1111/j.1365-2958.1996.tb02656.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a.PMID 8899709Read ↗

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Genetic modulation of Shigella flexneri 2a lipopolysaccharide O antigen modal chain length reveals that it has been optimized for virulence.Semantic proximity Read ↗

Relationship between O-antigen chain length and resistance to colicin E2 in Shigella flexneri.Semantic proximity Read ↗

Actin-based motility is sufficient for bacterial membrane protrusion formation and host cell uptake.Semantic proximity Read ↗

Structural and Biochemical Analysis of a Single Amino-Acid Mutant of WzzBSF That Alters Lipopolysaccharide O-Antigen Chain Length in Shigella flexneri.Semantic proximity Read ↗

Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction.Semantic proximity Read ↗

Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP.Semantic proximity Read ↗

OmpA and OmpC are critical host factors for bacteriophage Sf6 entry in Shigella.Semantic proximity Read ↗

Myosin IIA is essential for Shigella flexneri cell-to-cell spread.Semantic proximity Read ↗

Absence of O antigen suppresses Shigella flexneri IcsA autochaperone region mutations.Semantic proximity Read ↗

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