Article
Relationship between O-antigen chain length and resistance to colicin E2 in Shigella flexneri.
Microbiology (Reading, England) - 1 Mar 2014
Tran Elizabeth Ngoc Hoa, Papadopoulos Magdalene, Morona Renato
Abstract excerpt
The Shigella flexneri polysaccharide co-polymerase class 1a (PCP1a) protein, WzzBSF, regulates LPS O-antigen (Oag) chain length to confer short (S)-type Oag chains of ~10-17 Oag repeat units (RUs). The S-type Oag chains affect Shigella flexneri virulence as they influence IcsA-mediated actin-based motility. However, they do not confer resistance to complement; this is conferred by the very-long (VL)-type Oag...
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