Article
Effect of mutations in Shigella flexneri chromosomal and plasmid-encoded lipopolysaccharide genes on invasion and serum resistance.
Molecular microbiology - 1 May 1997
Hong M, Payne S M
Abstract excerpt
This study shows that both length and distribution of lipopolysaccharide (LPS) are important for Shigella flexneri invasion and virulence. Mutants were generated in the chromosomal LPS synthesis genes rfa, rfb, and rol, and in a plasmid-encoded O-antigen chain-length regulator, cld(pHS-2). LPS analysis showed that mutations in rfb genes and in a candidate rfaL gene either eliminated the entire O-antigen side...
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