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Article

mtDNA haplogroup J: a contributing factor of optic neuritis.

European journal of human genetics : EJHG - 1 Apr 1999

Reynier P, Penisson-Besnier I, Moreau C, Savagner F, Vielle B, Emile J, Dubas F, Malthièry Y

Abstract excerpt

Optic neuritis frequently occurs in multiple sclerosis (MS), and shares several similarities with the optic neuritis of Leber's hereditary optic neuropathy (LHON), which is mainly due to maternally transmitted mitochondrial DNA (mtDNA) mutations. Our report shows for the first time that a mitochondrial DNA background could influence the clinical expression of MS. One European mtDNA haplogroup was found only in MS...

Topics

Alleles
DNA, Mitochondrial
Female
Humans
Male
Multiple Sclerosis
Optic Neuritis
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10234520
DOI: 10.1038/sj.ejhg.5200293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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mtDNA haplogroup J: a contributing factor of optic neuritis.PMID 10234520Read ↗

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Analysis of the entire mitochondrial genome reveals Leber's hereditary optic neuropathy mitochondrial DNA mutations in an Arab cohort with multiple sclerosis.Semantic proximity Read ↗

Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations.Semantic proximity Read ↗

Leber’s hereditary optic neuropathy and multiple sclerosis: overlap between mitochondrial disease and neuroinflammationSemantic proximity Read ↗

Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients.Semantic proximity Read ↗

OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background.Semantic proximity Read ↗

No evidence of association between optic neuritis and secondary LHON mtDNA mutations in patients with multiple sclerosis.Semantic proximity Read ↗

Leber's hereditary optic neuropathy mutations in Korean patients with multiple sclerosis.Semantic proximity Read ↗

Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation.Semantic proximity Read ↗

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Mitochondrial haplogroups in Basque multiple sclerosis patients.Semantic proximity Read ↗

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