Article
Lack of association between mitochondrial DNA G15257A and G15812A variations and multiple sclerosis.
Journal of the neurological sciences - 15 Sept 2015
Andalib Sasan, Talebi Mahnaz, Sakhinia Ebrahim, Farhoudi Mehdi, Sadeghi-Bazargani Homayoun, Gjedde Albert
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is a debilitating disease of the central nervous system for which no definitive therapy has yet been developed. The etiology remains uncertain, but there is evidence of genetic susceptibility to the disease, including contributions from mitochondrial DNA (mtDNA) variations to the pathogenesis of MS. G15257A and G15812A are variations of the mtDNA tRNA(Thr) gene in MS sufferers...
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