Article
Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations.
Cellular and molecular neurobiology - 1 May 2009
Ghabaee Mojdeh, Omranisikaroudi Motahar, Amrisaroukolaei Shahla, Meysamie Alipasha, Sahraian Mohammad Ali, Bayati Asghar, Sanati Mohammad Hossein, Houshman Mossoud, Sadeghian Homa, Vajihazaman Khalili
Abstract excerpt
As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirmed with revised McDonald criteria and referred to Iranian Center of Neurological Research of Imam Khomeini hospital...
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