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Article

Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis.

International journal of cancer - 20 Mar 2004

Khodarev Nikolai N, Labay Edwardine, Darga Thomas, Yu Jianqing, Mauceri Helena, Gupta Nalin, Kataoka Yasushi, Weichselbaum Ralph R

Abstract excerpt

We performed expressional profiling of isogenic glioblastoma cell lines U87-Lux8 and U87-175.4. These cell lines differ in that U87-Lux8 expresses wild-type p53 and U87-175.4 expresses a dominant-negative p53 (175(His) mutation). DNA array analysis and real-time PCR measurements demonstrated that basal expression and response to irradiation were different in these isogenic glioblastoma cell lines. These...

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Identifiers

PMID: 14750172
DOI: 10.1002/ijc.11728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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