Article
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.
Genes & development - 15 Aug 2010
Inda Maria-del-Mar, Bonavia Rudy, Mukasa Akitake, Narita Yoshitaka, Sah Dinah W Y, Vandenberg Scott, Brennan Cameron, Johns Terrance G, Bachoo Robert, Hadwiger Philipp, Tan Pamela, Depinho Ronald A, Cavenee Webster, Furnari Frank
Abstract excerpt
Human solid tumors frequently have pronounced heterogeneity of both neoplastic and normal cells on the histological, genetic, and gene expression levels. While current efforts are focused on understanding heterotypic interactions between tumor cells and surrounding normal cells, much less is known about the interactions between and among heterogeneous tumor cells within a neoplasm. In glioblastoma multiforme...
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