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Article

Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.

Oncotarget - 31 May 2016

Stec Wojciech J, Rosiak Kamila, Siejka Paulina, Peciak Joanna, Popeda Marta, Banaszczyk Mateusz, Pawlowska Roza, Treda Cezary, Hulas-Bigoszewska Krystyna, Piaskowski Sylwester, Stoczynska-Fidelus Ewelina, Rieske Piotr

Abstract excerpt

Glioblastoma is the most common and malignant brain tumor, characterized by high cellular heterogeneity. About 50% of glioblastomas are positive for EGFR amplification, half of which express accompanying EGFR mutation, encoding truncated and constitutively active receptor termed EGFRvIII. Currently, no cell models suitable for development of EGFRvIII-targeting drugs exist, while the available ones lack the...

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Identifiers

PMID: 27004406
DOI: 10.18632/oncotarget.8201
PMCID: PMC5077985

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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