Article
Treatment with lipopolysaccharide enhances the pathogenicity of a low-pathogenic variant of Theiler's murine encephalomyelitis virus.
Journal of neuroscience research - 15 Sept 1996
Palma J P, Park S H, Kim B S
Abstract excerpt
Intracerebral infection of susceptible mouse strains with Theiler's murine encephalomyelitis virus (TMEV) results in an immune-mediated demyelinating disease (TMEV-IDD) similar to human multiple sclerosis (MS). Although the etiology of MS remains unknown, a role of an infectious agent has been im...
Topics
- Animals
- Cell Division
- Cytokines
- Disease Susceptibility
- Female
- Genetic Variation
- Immunodominant Epitopes
- Incidence
- Lipopolysaccharides
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Poliomyelitis
- RNA, Messenger
- T-Lymphocytes
- Th1 Cells
- Theilovirus